Loss of interest or pleasure in hobbies and activities, including sex
Decreased energy, fatigue, feeling "slowed down"
Difficulty concentrating, remembering, making decisions
Insomnia, early-morning awakening, or oversleeping
Low appetite and weight loss or overeating and weight gain
Thoughts of death or suicide, suicide attempts
Restlessness, irritability
Persistent physical symptoms that do not respond to treatment, such as headaches, digestive disorders and pain for which no other cause can be diagnosed.